CAA-0225
CAS No. : 244072-26-2
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| Cat. No. : | HY-16121 |
| M.Wt: | 487.55 |
| Formula: | C28H29N3O5 |
| Purity: | >98 % |
| Solubility: |
CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites[1][2][3]. IC50 & Target:IC50: 1.9 nM (TbCATL) In Vitro:CAA-0225 (10 mg/mL, 4 h) acts as a probe for autophagic protein hydrolysis by specifically inhibiting the involvement of protease L in the degradation of autophagosome membrane markers LC3-II and GABARAP[1]. CAA-0225 (0-100 μM, 48 h) kills Trypanosoma brucei parasite by inhibiting tissue protease L[3]. In Vivo:CAA-0225 (0.25 mg, i.v.) improves cardiac function and reduces infarct size by inhibiting the release of cardiac cathepsin L in a mouse model of reperfusion after myocardial infarction[2].
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