Norharmane
CAS No. : 244-63-3
(Synonyms: Norharman; β-Carboline)
| Size | Price | Stock |
|---|---|---|
| 1g | $19 | In-stock |
| 5g | $59 | In-stock |
| 10g | $109 | In-stock |
| 25g | $239 | In-stock |
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| Cat. No. : | HY-W008566 |
| M.Wt: | 168.20 |
| Formula: | C11H8N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 11 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings[1][2][3][4][5][6]. IC50 & Target:IC50: 4.7 μM (MAO-B), 6.5 μM (MAO-A)[1] In Vitro: Norharmane attenuates quinolinic acid formation by interferon-gamma-stimulated monocytes THP-1 cells and attenuates L-kynurenine formation, with IC50 values of 51 μM and 43 μM, respectively[4].
Norharmane has the potential for use as an antibiotic adjuvant to enhance the efficacy of conventional antibiotics to reduce pathogenic bacterial infections[6]. In Vivo: Norharmane (0-10 mg/kg, IP, once) shows an anxiety- and antidepressant-like behavior, and decreased locomotor activity[3].
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