(-)-Fucose
CAS No. : 2438-80-4
(Synonyms: 6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose)
| Size | Price | Stock |
|---|---|---|
| 1g | $7 | In-stock |
| 5g | $28 | In-stock |
| 10g | $34 | In-stock |
| 25g | $83 | In-stock |
| 100g | $296 | In-stock |
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| Cat. No. : | HY-N1480 |
| M.Wt: | 164.16 |
| Formula: | C6H12O5 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth[2].
In Vitro: (-)-Fucose (8-80 mM) inhibits the CL-11 binding to immobilized ligand and eliminates the trigger for complement activation with IC50 of 12.2 mM[2].
In Vivo: (-)-Fucose (100mg, i.p., single or double dosage) blocks the CL-11 associated complement C3d deposition on hypoxic renal tubules cells, reveals a protective effect against I/R injury with CL11 dependence in C57BL/6 mice[2].
(-)-Fucose (1-5 g/kg/d, i.p. for 11 days) inhibits tumor growth and mitotic activity, promotes tumor metastasis in solid Ehrlich tumour (SET) bearing NMRI mice[3].
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