Dexchlorpheniramine (maleate)
CAS No. : 2438-32-6
(Synonyms: S-(+)-Chlorpheniramine maleate salt)
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| Cat. No. : | HY-B1062 |
| M.Wt: | 390.86 |
| Formula: | C20H23ClN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : ≥ 100 mg/mL |
Dexchlorpheniramine maleate is an orally taken anti-histamine that has anti-inflammatory, anti-irritant, anti-allergic, and skin barrier effects. Dexchlorpheniramine maleate inhibits myocardial contraction in rats. Dexchlorpheniramine maleate can be used in studies of allergic rhinitis[1][2][3].
In Vitro:Dexchlorpheniramine maleate (0.00316-10 mg/mL) shows no phototoxicity in 3T3 cells, with an IC50 of 0.586 mg/mL[1].
Dexchlorpheniramine maleate promotes the synthesis of interleukin-1 (IL-1) under ultraviolet A (UVA) radiation[1].
Dexchlorpheniramine maleate has a protective effect against the synthesis of leukotriene B4 and nuclear factor κB (NF-κB) induced by UVA[1].
Dexchlorpheniramine maleate (3-300 μM) prolongs the QRS and RR intervals, inducing bradycardia in rats[2].
Dexchlorpheniramine maleate (1-100 μM) reduces the cardiac contractility in rats in a concentration-dependent manner, with an IC50 of 4.12 μM[2].
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