Valpromide
CAS No. : 2430-27-5
| Size | Price | Stock |
|---|---|---|
| 1g | $49 | In-stock |
| 5g | $240 | In-stock |
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| Cat. No. : | HY-B2117 |
| M.Wt: | 143.23 |
| Formula: | C8H17NO |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Valpromide is an amide derivative of Valproic acid (HY-10585) and an orally active epoxide hydrolase inhibitor that can cross the blood-brain barrier. Valpromide has antiepileptic, anticonvulsant, and antipsychotic effects. Valpromide also exhibits antiviral activity and can inhibit the reactivation of the EBV lytic cycle[1][2][3][4].
In Vitro:Valpromide (10 mM; 24-48 h) inhibits the expression of EBV lytic transactivator proteins Zebra, BZLF1, and BRLF1 in EBV-positive HH514-16 cells[1].
Valpromide (10 mM; 18 h) inhibits the expression of BZLF1 and BRLF1 in EBV-infected Raji cells[1].
In Vivo:Valpromide (3 mmol/kg; subcutaneous injection; single administration) induces a much lower rate of exencephaly in NMRI mice compared with Valproic acid (HY-10585)[3].
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