Zoniporide (hydrochloride)
CAS No. : 241800-97-5
(Synonyms: CP-597396 (hydrochloride))
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| Cat. No. : | HY-105064B |
| M.Wt: | 356.81 |
| Formula: | C17H17ClN6O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM)[1][2].
IC50 & Target:IC50: 14 nM (NHE-1)[1]
In Vivo: Zoniporide (0.25-4 mg/kg; i.v.; every hour for 2 hours) elicits a dose-dependent reduction in infarct size (ED50=0.45 mg/kg/h) in open chest anesthetized rabbits[1].
Zoniporide exhibits moderate plasma protein binding, has a t1/2 of 1.5 hours in monkeys, and has one major active metabolite[1].
Zoniporide treatment shows the AUC0-∞ and t1/2 are 0.07 μg h/mL and 0.5 hours, respectively[2].
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