18-Oxocortisol
CAS No. : 2410-60-8
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| Cat. No. : | HY-113151 |
| M.Wt: | 376.44 |
| Formula: | C21H28O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3]. In Vivo: Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high[3].
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