AL-438
CAS No. : 239066-73-0
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| Cat. No. : | HY-114154 |
| M.Wt: | 347.45 |
| Formula: | C23H25NO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2].
IC50 & Target:Ki: 2.5 nM (glucocorticoid receptor)[1]
In Vitro:AL-438 (1 µM) decreases the LPS-induced IL-6 production in ATDC5 cells[1].
AL-438 (0-1 µM; 1 h+24 h) inhibits IL-1β (2 ng/ml) induced IL-6 expression in HSKF1501 cells[2].
In Vivo:AL-438 (1, 10, 100 mg/kg; p.o.) shows anti-inflammatory activity in rats[2].
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- HY-114154
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