Pogostone

Pogostone is isolated from patchouli oil with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml ^[2]. Pogostone induces cell apoptosis and autophagy^[2]. IC50 & Target:IC50: apoptosis; autophagy; bacteria^[1][2] In Vitro: Pogostone shows inhibitory effects on HCT116 cell with an IC₅₀ value of 18.7±1.93 µg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC₅₀: 95.13±19.44 µg/ml) and endothelial cell HUVEC (IC₅₀: 112±20.77 µg/ml)^[1].
In Vivo: Pogostone ( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively^[2].