DNQX
CAS No. : 2379-57-9
(Synonyms: FG 9041)
| Size | Price | Stock |
|---|---|---|
| 25mg | $66 | In-stock |
| 50mg | $106 | In-stock |
| 100mg | $145 | In-stock |
| 200mg | $238 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-15067 |
| M.Wt: | 252.14 |
| Formula: | C8H4N4O6 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 35 mg/mL;H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
DNQX (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1]. IC50 & Target:Non-NMDA Glutamate Receptor[1] In Vitro:DNQX selectively depolarizes thalamic reticular nucleus (TRN) neurons[2]. In Vivo:DNQX, a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μL of 0.5 mg/mL) significantly diminishes phencyclidine (PCP) (40 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex[3].
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