Lanuginosine
CAS No. : 23740-25-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $765 | In-stock |
| 10mg | $1225 | In-stock |
| 25mg | $2450 | In-stock |
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| Cat. No. : | HY-119398 |
| M.Wt: | 305.28 |
| Formula: | C18H11NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 0.5 mg/mL (ultrasonic;warming;adjust pH to 2 with 1 M HCl;heat to 60°C) |
Lanuginosine is an alkaloid. Lanuginosine can be isolated from the stems of Xylopia laevigata (Annonaceae) and the leaves of Magnolia grandiflora. Lanuginosine induces Apoptosis. Lanuginosine inhibits AChE (IC50: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine exhibits anticancer activity against hepatocellular carcinoma, human promyelocytic leukemia, human chronic myeloid leukemia, melanoma, and brain tumors. Lanuginosine can be used in the research of Alzheimer's disease[1][2][3].
IC50 & Target:10.9 μM (AChE)[1]
In Vitro:Lanuginosine (72 h) shows cytotoxic activity against B16-F10, HepG2, HL-60, and K562 tumor cell lines[1].
Lanuginosine (10-20 μg/mL; 24 h) induces apoptosis in HepG2 cells[1].
Lanuginosine is cytotoxic to U251 cells (a brain tumor cell line) with an IC50 of 4 μg/mL[2].
Lanuginosine (Compound 12) is an AChE inhibitor (IC50: 10.9 μM)[3].
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