3,4-Methylenedioxycinnamic acid
CAS No. : 2373-80-0
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|---|---|---|
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| 10g | $12 | In-stock |
| 25g | $18 | In-stock |
| 100g | $52 | In-stock |
| 500g | $257 | In-stock |
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| Cat. No. : | HY-W009993 |
| M.Wt: | 192.17 |
| Formula: | C10H8O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
3,4-Methylenedioxycinnamic acid is an inhibitor of the 4-hydroxycinnamoyl-CoA ligase (4CL) with a Ki of 100 μM. 3,4-Methylenedioxycinnamic acid exhibits the Km value for the substrate ferulic acid of 4CL is 8.4 μM.3,4-Methylenedioxycinnamic acid increases the formation of soluble phenolics in particular of vanillic acid. 3,4-Methylenedioxycinnamic acid demonstrates larvicidal activity[1][2].
In Vitro:3,4-Methylenedioxycinnamic acid (1-1000 μM, 24 h) exhibits LC50 and LC90 values of 28.9 and 162.7 μM against Aedes aegypti, respectively[2].
3,4-Methylenedioxycinnamic acid (5.2-5200 μM, 1-24 h) does not exhibit acetylcholinesterase inhibitory activity and is not cytotoxic to PBMCs[2].
In Vivo:3,4-Methylenedioxycinnamic acid (2000 mg/kg, p.o., single dose) exhibits safety characteristics in mice (high selectivity index, no neurotoxicity, no tissue damage)[2].
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