Vicenin 2
CAS No. : 23666-13-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $260 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N2165 |
| M.Wt: | 594.52 |
| Formula: | C27H30O15 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic) |
Vicenin 2, a flavonoid, is an orally active angiotensin-converting enzyme (ACE) inhibitor (IC50 of 43.83 μM)[1]. Vicenin 2 has radioprotective, anti-nociceptive effects, anti-glycation anti-inflammatory, antioxidant, anticancer, antiangiogenic properties[2][3].
In Vitro:Vicenin 2 (10-100 µM; 24 hours) shows cytotoxic effect in a dose-dependent manner in NCI‑H23 cells. Vicenin 2 increases caspase-3 activity, increases DNA fragmentation, increasesd the levels of Rad50 and lowers levels of MMP-2 and p21 proteins while being non-toxic and radioprotective to the fibroblast cells[2].
In Vivo:Vicenin 2 (50 mg/kg; orally administration; for 7 days) effectively reduces the MPO activity, attenuates the expression of pro-inflammatory cytokines and key inflammatory markers, in DSS-induced colitis mice[3].
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