Lankacidin C
CAS No. : 23623-31-6
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| Cat. No. : | HY-121412 |
| M.Wt: | 459.53 |
| Formula: | C25H33NO7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lankacidin C is an inhibitor of protein synthesis in vitro. Lankacidin C inhibits the activity of L1210 leukemia, B16 melanoma and 6C3 HED/OG lymphosarcoma cell lines. Lankacidin C has antibacterial activity and antitumor activity[1][2].
In Vivo: Lankacidin C (75-1000 mg/kg; i.p.; once daily for 5 d) prolongs the mean survival time of (C57BL/6×DBA/2) F1 (BDF1) mice with dose-dependent manner. Lankacidin C (1000 mg/kg) significantly inhibits the growth of B-16 melanoma in C57BL/6 mice implanted B-16 melanoma[2].
Lankacidin C (300 mg/kg; i.p.; once daily for 6 d) inhibits the activity of L-1210 cells that resistance to 6-Mercaptopurine (HY-13677) or Cytosine Arabinoside (HY-13605) in BDF1 mice bearing L-1210/6-Mercaptopurine or L-1210/Cytosine Arabinoside[2].
Lankacidin C (10-100 mg/kg; i.p.; once daily for 5 d) significantly prolongs the mean survival time of C3H/He mice bearing 6C3HED/OG or 6C3HED/RG lymphosarcoma[2].
Lankacidin C (500 mg/kg; i.p.; once daily for 3 or 4 d) suppresses the production of antibody against sheep erythrocytes in ICR mice when administered before or after antigenic stimulation[2].
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