[Arg14,Lys15]Nociceptin
CAS No. : 236098-40-1
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| Cat. No. : | HY-P1301 |
| M.Wt: | 1909.16 |
| Formula: | C82H137N31O22 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1]. In Vitro: [Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2]. In Vivo: In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].
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