8-Bromo-cAMP
CAS No. : 23583-48-4
(Synonyms: 8-Br-Camp)
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| Cat. No. : | HY-12306A |
| M.Wt: | 408.10 |
| Formula: | C10H11BrN5O6P |
| Purity: | >98 % |
| Solubility: | H2O : 5.74 mg/mL (ultrasonic;warming;adjust pH to 9 with 1 M NaOH;heat to 60°C) |
8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells[1][2].
IC50 & Target:PKA[1]
In Vitro:8-Bromo-cAMP (0.1/0.5 mM) enhances the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells, and 0.1 mM of 8-Bromo-cAMP shows a synergistic effect with Valproic acid (HY-10585) (0.5 mM)[1].
8-Bromo-cAMP (20 μM, 24 and 48 h) induces apoptosis in esophageal cancer cell line (Eca-109)[2].
8-Bromo-cAMP (0.5 mM, 2 days) induces decidualization of human endometrial stromal cells[3].
In Vivo:8-Bromo-cAMP (60 mg/kg/day, i.p., 7 days) reduces tumor in CT26 tumor mice[4].
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