Procyanidin B3

Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis^{[1][2][3][4][5]}. IC50 & Target:p300^[1] In Vitro:Procyanidin B3 (50 and 100 μM, 1 h) inhibits the AR(androgen receptor)-dependent promoter activity induced by the synthetic androgen R1881 in LNCaP cells^[1].
Procyanidin B3 (25-100 μM, 1 h) inhibits p300 HAT activity and p300-mediated AR (androgen receptor) acetylation in a dose-dependent manner in LNCaP cells^[1].
Procyanidin B3 (50 μM, 12 hours) enhances the antagonistic effect of Flutamide (HY-B0022) by inhibiting p300 activity^[1].
Procyanidin B3 (40 μM, 24 and 48 h) significantly upregulates the cell viability of human nucleus pulposus (NP) cells^[4].
Procyanidin B3 (2.5-40 μM, 24 h) inhibits the inflammatory effects in human nucleus pulposus (NP) cells exposed to lipopolysaccharide (HY-D1056)^[4].
In Vivo:Procyanidin B3 (100 mg/kg, p.o., 5 days a week for 4 weeks) prevents articular cartilage degeneration and heterotopic cartilage formation in a surgically-induced osteoarthritis mice model^[2].
Procyanidin B3 (30 mg/kg, p.o., once daily for 4 weeks) delays the development of intervertebral disc degeneration (IVDD) in a Lipopolysaccharides (HY-D1056)-induced IVDD Sprague-Dawley rats model^[2].