Daunorubicin (hydrochloride)
CAS No. : 23541-50-6
(Synonyms: Daunomycin (hydrochloride); RP 13057 (hydrochloride); Rubidomycin (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $41 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $105 | In-stock |
| 50mg | $150 | In-stock |
| 100mg | $250 | In-stock |
| 200mg | $380 | In-stock |
| 500mg | $594 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-13062 |
| M.Wt: | 563.98 |
| Formula: | C27H30ClNO10 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 34 mg/mL;DMSO : 50 mg/mL (ultrasonic) |
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor[1][2][4][5].
IC50 & Target: Topoisomerase II[1]
In Vitro: Daunorubicin hydrochloride (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells[2].
Daunorubicin hydrochloride (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells[3][4].
Daunorubicin hydrochloride (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells[4].
Daunorubicin hydrochloride (0.4 μM, 120 min) induces ROS generation in L3.6 cells[4].
Daunorubicin hydrochloride (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line)[6].
In Vivo: Daunorubicin hydrochloride (intravenous injection, 3 mg/kg, three times at 48 h intervals.) produces cardiotoxicity and nephrotoxicity in rats[5].
Daunorubicin hydrochloride (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice[7].
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