U-99194 (maleate)
CAS No. : 234757-41-6
(Synonyms: U-99194A; PNU-99194A (maleate); JPC-211 (maleate))
| Size | Price | Stock |
|---|---|---|
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| 10mg | $160 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $430 | In-stock |
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| Cat. No. : | HY-12701A |
| M.Wt: | 393.47 |
| Formula: | C21H31NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : 20 mg/mL (ultrasonic) |
U-99194 (PNU-99194) maleate is a selective, potent dopamine D3 receptor antagonist (Ki =160 nM). U-99194 maleate inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 maleate abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 maleate significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 maleate can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors[1][2].
In Vitro:U-99194 (1 μM, 15 min) maleate prevents the cocaine-induced inhibition of monosynaptic inhibitory postsynaptic currents (IPSCs) evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].
U-99194 (1 μM) maleate blocks the inhibitory effect of PD 128907 ( HY-100539) on the amplitude of monosynaptic IPSCs evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].
In Vivo:U-99194 (30 mg/kg, i.p., once) maleate significantly suppresses Nicotine (HY-127019)-induced tremor in mice[1].
U-99194 (30 μg/site, intracerebellar microinjection, once) maleate markedly inhibits Nicotine-induced tremor in rats[1].
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