Alkannin
CAS No. : 23444-65-7
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| Cat. No. : | HY-119874 |
| M.Wt: | 288.30 |
| Formula: | C16H16O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent[1].
In Vitro: Alkannin is a potent and specific inhibitor to PKM2, an enzyme that dictates the last rate-limiting step of glycolysis, which is essential for cancer cells’ proliferation and survival. In the absence of D-fructose-1,6-bisphosphate (FBP), the IC50 of Alkannin is 0.3?μM. In the presence of FBP (125?μM), the IC50 of Alkannin is 0.9?μM, respectively. Alkannin effectively inhibits the cellular glycolytic flux in cancer cells dominantly expressing PKM2[1].
Alkannin (2.5-20?μM, 1 hour) inhibit the rates of cellular lactate production and glucose consumption[1].
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