Emodin-8-glucoside
CAS No. : 23313-21-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $45 | In-stock |
| 5mg | $93 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $215 | In-stock |
| 50mg | $320 | In-stock |
| 100mg | $475 | In-stock |
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| Cat. No. : | HY-N0311 |
| M.Wt: | 432.38 |
| Formula: | C21H20O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier[1][2][3][4][5].
In Vitro:Emodin-8-glucoside reduces the release of lactate dehydrogenase (LDH), increases the mitochondrial activity, exhibiting a protective effect from neuronal damage[3].
In Vivo:Emodin-8-glucoside (2-10 mg/kg, iv, single dose) exhibits neuroprotective activity in rats cerebral ischemia-reperfusion models[3].
Emodin-8-glucoside (2.5-10 mg/kg/day) exhibits a protective effect on renal function, ameliorates the renal fibrosis in mouse unilateral ureteral obstruction (UUO) model[4].
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