Benzocaine (hydrochloride)
CAS No. : 23239-88-5
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| Cat. No. : | HY-Y0258A |
| M.Wt: | 201.65 |
| Formula: | C9H12ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Benzocaine hydrochloride is an orally active local anesthetic. Benzocaine hydrochloride non-competitively inhibits the binding of Ca-ATPase to Ca2+, with an IC50 of 47.1 mM. Benzocaine hydrochloride exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine hydrochloride induces methemoglobinemia in various experimental animals[1][2][3]. In Vitro:Benzocaine hydrochloride (0.1-3.0 mM; 1 mM) persistently blocks wild-type µ1 muscle voltage-gated Na+ channels expressed in HEK293t cells, with an IC50 of 0.8 mM[1].
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