3-Deazauridine
CAS No. : 23205-42-7
(Synonyms: NSC 126849)
| Size | Price | Stock |
|---|---|---|
| 100mg | $74 | In-stock |
| 250mg | $168 | In-stock |
| 1g | $517 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-105336 |
| M.Wt: | 243.21 |
| Formula: | C10H13NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1].
IC50 & Target:Cytidine triphosphate synthase[1]
In Vitro: 3-Deazauridine (DAUR) exhibits superior antitumor activity against L1210 leukemia cells[1].
In Vivo: 3-Deazauridine (DAUR) (250 mg/kg/day; i.p; 1-9 days) shows moderate activity against L1210 leukemia cells in mice[1].
3-Deazauridine (ip; 5 times doses) has the lethal dose of 250 mg/kg/day and 417 mg/kg/day, the toxic dose low of 62.5 mg/kg/day and 104 mg/kg/day, the highest non-toxic dose of 31.25 mg/kg/day and 52 mg/kg/day, in beagle dogs and rhesus monkeys, respectively[1].
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