Senkirkin
CAS No. : 2318-18-5
(Synonyms: Senkirkine; Renardin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $310 | In-stock |
| 5mg | $615 | In-stock |
| 10mg | $920 | In-stock |
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| Cat. No. : | HY-122509 |
| M.Wt: | 365.42 |
| Formula: | C19H27NO6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Senkirkin is a pyrrolizidine alkaloid derived from Tussilago farfara. Senkirkin induces chromosomal damage in lymphocytes and is metabolized by CYP3A4[1][2].
In Vitro:Senkirkin binds to human CYP3A4[1].
Senkirkin (100 μM; 10 min preincubation, 60 min incubation with NADPH) is metabolized by cDNA-expressed human CYP3A4 and human liver microsomes[1].
Senkirkin (50-1000 μM; 24 hours) exhibits weak mitosis-inhibitory activity, and reduces the mitotic index to 24.5% at the concentration of 1000 μM in in vitro stimulated human primary lymphocytes[2].
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