Fosfomycin
CAS No. : 23155-02-4
(Synonyms: MK-0955)
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| Cat. No. : | HY-B1075A |
| M.Wt: | 138.06 |
| Formula: | C3H7O4P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].
In Vivo: Fosfomycin (80 mg/kg; i.v. or p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes in rats[3].
Pharmacokinetic of Fosfomycin in Rats[4]
| Dibekacin Dose (mg) | Vdss (l/kg) | β (min-1) | T1/2 (min) | Urinary recovery (%) |
| 30 | 0.261 | 0.0244 | 28.4 | 85 |
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