CP-544439
CAS No. : 230954-09-3
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| 10mg | $1961 | Get quote |
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| Cat. No. : | HY-107013 |
| M.Wt: | 410.42 |
| Formula: | C18H19FN2O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2]. In Vivo: In vivo studies using a hamster model, in which the cartilage collagen degradation was induced by intra-articular injection of recombinant human MMP-13, demonstrated that oral administration of CP-544439 inhibits degradation of the cartilage collagen with an ED50 of 14 mg/kg and efficacious plasma concentrations ranging from 0.5 to 1.0 g/ml[1].
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