Tetramethyluric acid
CAS No. : 2309-49-1
(Synonyms: 1,3,7,9-Tetramethyluric acid; Theacrine)
| Size | Price | Stock |
|---|---|---|
| 5g | $13 | In-stock |
| 25g | $32 | In-stock |
| 100g | $121 | In-stock |
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| Cat. No. : | HY-119575 |
| M.Wt: | 224.22 |
| Formula: | C9H12N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 25 mg/mL (ultrasonic) |
Tetramethyluric acid (1,3,7,9-Tetramethyluric acid) is an orally active purine alkaloid in Coffea species and Camellia kucha. Tetramethyluric acid exhibits antiviral, and anti-inflammatory activity. Tetramethyluric acid can be used for the research of inflammation disease, and influenza virus infection[1][2][3][4][5].
In Vitro:Tetramethyluric acid (50-100 μM) exhibits anti-influenza virus activity in MDCK cells, inhibiting NS1 protein expression[1].
Tetramethyluric acid (1.5×10-2 M) reduces 32P-labelled orthophosphate incorporation into DNA and RNA and increases ATP levels by 40% in excised Vicia faba root tips[2].
Tetramethyluric acid (2×10-2 M; 120 min) induces chromosomal aberrations in Vicia faba root tips[2].
In Vivo:Tetramethyluric acid (10 mg/kg; p.o.) upregulates collagen II, SIRT3, FOXO3a, and SOD2 expression to improve intervertebral disc degeneration in mice[1].
Tetramethyluric acid (20 mg/kg; i.g.) improves cardiac function in ovariectomized mice with myocardial infarction by activating SIRT3 and reducing myocardial fibrosis and apoptosis[1].
Tetramethyluric acid (8-32 mg/kg; p.o.; single dose) significantly inhibits Xylene-induced ear edema and λ-Carrageenan (HY-N9470)-induced hind paw edema[1].
Tetramethyluric acid (10-30 mg/kg; p.o.; daily; 7 days) reduces hepatic inflammation and liver damage in restraint-stressed mice[1].
Tetramethyluric acid (12.5-25.0 mg/kg; p.o.) attenuates FIA-induced rheumatoid arthritis in SD rats via the TGF-β/SMAD pathway[1].
Tetramethyluric acid (24-48 mg/kg; i.p.; single pre-treatment dose) significantly attenuates adenosine receptor agonist-induced motor depression in Long Evans rats via adenosergic and dopaminergic systems[1].
Tetramethyluric acid (5-15 mg/kg; p.o.) reverses restraint stress-induced learning and memory impairment in male Kunming mice[1].
Tetramethyluric acid (3-30 mg/kg; i.g.) produces antidepressant effects in male NIH mice by modulating monoamine neurotransmitters[1].
Tetramethyluric acid (10-20 mg/kg; p.o.) ameliorates HFD-induced NAFLD in C57BL/6 mice via the SIRT3/LCAD signaling pathway[1].
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