L-AP4
CAS No. : 23052-81-5
(Synonyms: L-APB)
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|---|---|---|
| 1mg | $170 | In-stock |
| 5mg | $420 | In-stock |
| 10mg | $700 | In-stock |
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| Cat. No. : | HY-100781A |
| M.Wt: | 183.10 |
| Formula: | C4H10NO5P |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic) |
L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].
IC50 & Target: EC50: 0.13 μM (mGlu4), 0.29 μM (mGlu8), 1.0 μM (mGlu6), 249 μM (mGlu7)[1].
In Vivo: L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2].
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