BUR1
CAS No. : 23000-46-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $1110 | In-stock |
| 50mg | $1355 | Get quote |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-121025 |
| M.Wt: | 279.34 |
| Formula: | C16H17N5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BUR1 is a BMP upregulator (EC50: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline (HY-N0750) induced rats[1].
In Vitro:BUR1 (0.2 μM, 15 min-24 h) increases expression of Inhibitor of DNA binding 1 (Id1) and phosphorylation of Smad1/5 in PAECs[1].
In Vivo:BUR1 (4.5 mg/day, i.g., 3 weeks) reverses MCT-induced pulmonary arterial pressure and right ventricular systolic pressure in rats[1].
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