EPI-001
CAS No. : 227947-06-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $88 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $260 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-100348 |
| M.Wt: | 394.89 |
| Formula: | C21H27ClO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (84.40 mM; Need ultrasonic) |
EPI-001, a selective inhibitor of Androgen Receptor (AR), targets transactivation unit 5 (Tau-5) of the AR. EPI-001 can inhibit transactivation of the AR amino-terminal domain (NTD), with an IC50 of ~6 μM. EPI-001 is also a selective modulator of PPARγ. EPI-001 is active against castration-resistant prostate cancer[1][2][3].
IC50 & Target: IC50: 6 μM (AR NTD)[1]
In Vitro: EPI-001 (5-100 μM; 7 d) inhibits PCa/CRPC cell growth in a dose-dependent manner[2].
EPI-001 (50 μM) inhibits endogenous AR mRNA and protein expression in PCa and CRPC cell lines[2].
EPI-001 (50 μM) inhibits transcriptional activity of both AR TAU1 and TAU5[2].
In Vivo: EPI-00 (20 mg/kg; i.v. every 5 d for 25 d) inhibits the growth of tumors and has no general toxicity in vivo[1].
EPI-00 (50 mg/kg; i.v.) blocks the androgen-axis and inhibits androgen-dependent tumor growth[1].
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