Oxyclozanide
CAS No. : 2277-92-1
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| Cat. No. : | HY-17594 |
| M.Wt: | 401.46 |
| Formula: | C13H6Cl5NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity[1][2][3]. IC50 & Target:Parasite[1] In Vitro:Oxyclozanide inhibits meticillin-sensitive S. pseudintermedius isolates with MIC values of 0.5-1 μg/mL[3]. Oxyclozanide inhibits meticillin-resistant S. pseudintermedius isolates with MIC values of 0.5-2 μg/mL[3]. Oxyclozanide inhibits methicillin-resistant S. aureus (MRSA) with a MIC value of 1 μg/mL[3]. In Vivo:Oxyclozanide (15 mg/kg (sheep), 10 mg/kg (cattle); oral administration) shows antiparasitic effectiveness in sheep and cattle[1]. Oxyclozanide (1500-5000 mg/kg; oral administration, once) induces multiple toxic symptoms in acute toxicity test of rats[2].
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