1-Linoleoyl Glycerol
CAS No. : 2277-28-3
(Synonyms: 1-Linoleoyl-rac-glycerol; 1-Monolinolein)
| Size | Price | Stock |
|---|---|---|
| 25mg | $70 | In-stock |
| 50mg | $96 | In-stock |
| 100mg | $150 | In-stock |
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| Cat. No. : | HY-111346 |
| M.Wt: | 354.52 |
| Formula: | C21H38O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;Ethanol : 100 mg/mL (ultrasonic) |
1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6)[1][2][3].
IC50 & Target:The (R)-1-Linoleoyl Glycerol and (S)-1-Linoleoyl Glycerol exhibit Lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitory activities with IC50 values of 45.0 and 52.0 μM, respectively[1].
In Vitro:1-LG (3 µM, 5 min) is metabolized by human eosinophils to 13-HODE-G and 13-HODE, with 13-HODE being the predominant[2].
1-LG (3 µM) is metabolized by human neutrophils to produce 15-LO metabolite[2].
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