Aminocandin
CAS No. : 227472-48-2
(Synonyms: HMR 3270; IP960; NXL201)
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| Cat. No. : | HY-P0068 |
| M.Wt: | 1102.28 |
| Formula: | C56H79N9O14 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Aminocandin (HMR 3270) is water-soluble antifungal drug of the echinocandin class with excellent activity against Aspergillus and Candida spp.[1].
IC50 & Target:Fungal[1]
In Vitro: Aminocandin (HMR 3270) inhibits Fluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L[2].
Aminocandin shows half-life of 48-58 h[2].
In Vivo: Aminocandin (1-10 mg/kg; i.v. or i.p.; once daily for 11 days) is highly effective in reducing mortality and organ burden in disseminated infection caused by ITC-susceptible and -resistant A. fumigatus in mice[1].
Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused by Fluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice[2].
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