HDACs/mTOR Inhibitor 1
CAS No. : 2271413-06-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $450 | In-stock |
| 10mg | $750 | In-stock |
| 50mg | $2250 | In-stock |
| 100mg | $3350 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-114414 |
| M.Wt: | 566.65 |
| Formula: | C28H38N8O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 32.5 mg/mL (ultrasonic) |
HDACs/mTOR Inhibitor 1 is a dual HDACs and mTOR inhibitor, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM for HDAC1, HDAC6, mTOR, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induces tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 can be used in the research of hematologic malignancies[1][2].
IC50 & Target:IC50: 0.19 nM (HDAC1),1.8 nM (HDAC6), 1.2 nM (mTOR), >500 nM (PI3Kα)[1].
In Vitro:HDACs/mTOR Inhibitor 1 (Compound 12l) inhibits leukemia cells proliferation with IC50s of 4.05, 9.01, 9.98 μM for MV4-11, OCI-AML2, OCI-AML3 cells[1].
HDACs/mTOR Inhibitor 1 (0-10 μM, 6 h or 24 h) downregulates p-ERK and increases Ac-H3 in MV4-11 cells[1].
HDACs/mTOR Inhibitor 1 (10 to 1000 nM, 48 h) reduces S-phase cells and increases the percentage of cells in G0/G1 phase in MV4-11 cells[1].
In Vivo:HDACs/mTOR Inhibitor 1 (Compound 12l) (10 or 20 mg/kg, i.v.) inhibits tumor growth without significant toxicity in MV4-11 and MM1S xenograft NOD/SCID mouse model[1].
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