AZ 11645373
CAS No. : 227088-94-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $65 | In-stock |
| 5mg | $135 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $630 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-108670 |
| M.Wt: | 463.51 |
| Formula: | C24H21N3O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors，AZ11645373 inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells , with an IC50 value of 90 nM[1].
In Vitro:AZ11645373 produces a concentration-dependent inhibition of BzATP-mediated calcium transients, with complete inhibition observed at concentrations between 100 and 300 nM according to concentration-inhibition curves[1].
AZ11645373 inhibits ATP- or BzATP-evoked YO-PRO1 fluorescence in HEK cells stably expressing hP2X7R, but not in cells expressing rP2X7R, with an KB value not significantly different from those obtained in experiments measuring membrane currents or calcium mobilization[1].
AZ11645373 (0.01, 0.1, 1 μM; 30 min) has no significant effect on basal levels of IL-1β in culture medium of LPS-treated cells, but produces a concentration-dependent inhibition of ATP-mediated IL-1β release with a calculated KB value of 92 nM[1].
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