LB42708
CAS No. : 226929-39-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $43 | In-stock |
| 5mg | $89 | In-stock |
| 10mg | $137 | In-stock |
| 25mg | $275 | In-stock |
| 50mg | $413 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-15879 |
| M.Wt: | 555.47 |
| Formula: | C30H27BrN4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
LB42708 is a potent, selective and orally active farnesyltransferase inhibitor. LB42708 inhibits farnesylation of H-Ras, N-Ras and K-Ras4B with IC50s of 0.8 nM, 1.2 nM and 2.0 nM, respectively[1]. In Vitro: LB42708 induces cell death despite K-ras prenylation. Growth inhibition by LB42708 is accompanied by G1 and G2/M cell cycle arrests in H-ras and K-ras-transformed RIE cells, respectively. LB42708 induces the upregulation of p21(CIP1/WAF1) and RhoB above the basal level that leads to the cell cycle arrest and to distinct morphological alterations of ras-transformed rat intestinal epithelial (RIE) cells[2].
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