RU.521
CAS No. : 2262452-06-0
(Synonyms: RU320521)
| Size | Price | Stock |
|---|---|---|
| 1mg | $48 | In-stock |
| 5mg | $120 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $335 | In-stock |
| 50mg | $475 | In-stock |
| 100mg | $700 | In-stock |
| 500mg | $1750 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-114180 |
| M.Wt: | 415.23 |
| Formula: | C19H12Cl2N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS)[1]. IC50 & Target:IC50: 0.7 μM (dsDNA)[1] In Vitro: RU.521 (0.1 nM-1000 μM; 72 h) suppresses dsDNA-induced signaling in macrophage cells[1]. RU.521(0-100 μM; 24 h) selectively inhibits cGAS-mediated signaling[1]. In Vivo: RU.521 (5 mg/kg ; i.p. once) reduces symptoms from sepsis in mice[2].
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