Demethoxycurcumin

Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research^{[1][2][3][4][5]}. In Vitro:Demethoxycurcumin (0-150 μM, 0-96 h) exerts anti-inflammatory effect on Caco-2 cells of in vitro inflamed human intestinal mucosa model by inhibiting NO secretion induced by iNOS^[1].
Demethoxycurcumin (35 μM, 48 h) can change the expression of DNA damage, cell cycle and apoptosis-related genes in human lung cancer NCI-H460 cells, and exhibit anticancer activity^[2].
The IC₅₀ values of Demethoxycurcumin (2-1024 μg/mL, 12-14 h) forE. coli, S. aureus, and S. dysenteriae are 212.5, 282.5 and 465.0 μg/mL, and the MIC values are 512, 1024 and 1024 μg/mL, respectively^[5].
In Vivo:Demethoxycurcumin (3-30 mg/kg/day for 5 days or 20 days, i.p.) regulates the expression of inflammatory and apoptotic genes in the hippocampus and frontal cortex of rat models infused with Aβ + Ibotenic acid (HY-N2311) and helps to improve Alzheimer's disease^[3].
Demethoxycurcumin (10 mg/kg/day for 28 days, p.o.) can enhance cognition and enhance choline acetyltransferase (ChAT) activity in mice induced by Scopolamine (HY-N0296) ^[4].