Tricarbonyldichlororuthenium(II) dimer
CAS No. : 22594-69-0
(Synonyms: CORM-2)
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| Cat. No. : | HY-W033577 |
| M.Wt: | 512.01 |
| Formula: | C6H6Cl4O6Ru2 |
| Purity: | >98 % |
| Solubility: | DMSO : 30 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium(II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium(II) dimer has CO-independent functional effects on multiple potassium channels[1][2][3][4].
In Vitro:Tricarbonyldichlororuthenium(II) dimer (100 μM; 5-10 min) can activate non-selective cation currents in human umbilical vein endothelial cells, and this occurs independently of CO release[1].
Tricarbonyldichlororuthenium(II) dimer (12.5-100 μM; 3-48 h) exerts anti-inflammatory activity in RAW264.7 cells treated with LPS (Prevotella intermedia)[2].
In Vivo:Tricarbonyldichlororuthenium(II) dimer (1-10 mg/kg; oral gavage; single dose) has a protective effect in a rat model of gastric mucosal injury induced by ischemia-reperfusion[3].
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