Alexidine
CAS No. : 22573-93-9
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| Cat. No. : | HY-B1474 |
| M.Wt: | 508.79 |
| Formula: | C26H56N10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1].
In Vitro: Alexidine (10?μM, 24 hours) treatment can decimate the biofilm community[1].
Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells[1].
In Vivo: Alexidine (Jugular vein-catheterized; 48 hours; 3?μg/ml; once) can decimate preformed biofilms growing in the jugular vein catheters of mice[1].
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