SJFα
CAS No. : 2254609-27-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $260 | In-stock |
| 10mg | $490 | In-stock |
| 25mg | $1020 | In-stock |
| 50mg | $1800 | In-stock |
| 100mg | $3100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114404 |
| M.Wt: | 1120.27 |
| Formula: | C59H67F2N7O11S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
SJFα is a selective p38α PROTAC degrader with a DC50 of 7.16 nM and Dmax of 97.4%. SJFα is far less effective at degrading p38δ (DC50 = 299 nM). SJFαcan be used for the research of cancer, such as breast cancer[1]. (Structure Note: Pink: p38α ligand (HY-45124); Blue: VHL ligand (HY-125845))
IC50 & Target:DC50: 7.16±1.03 nM (p38α)[1]
PROTAC[1]
In Vitro:SJFα (0.025-2.5 μM, 6-72 h) degrades p38α in MDA-MB-231 cells[1].
SJFα(0.025-2.5 μM) does not degrade the other p38 isoforms (β and γ) in MDA-MB-231 cells[1].
SJFα (0.025-2.5 μM) reduces p38δ:PROTAC:VHL complex in MDA-MB-231 cells[1].
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