(R)-ND-336
CAS No. : 2252493-33-5
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| Cat. No. : | HY-124373A |
| M.Wt: | 371.90 |
| Formula: | C16H18ClNO3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(R)-ND-336 is a potent and selective MMP-9 inhibitor with a Ki of 19 nM. (R)-ND-336 inhibits MMP-2 (Ki=127 nM) and MMP-14 (Ki=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research[1].
In Vitro: (R)-ND-336 poorly inhibits other MMPs (Ki>100 μM). (R)-ND-336 has a long residence time (the time the inhibitor is bound to MMP-9, calculated as 1/koff) of 300 min[1].
A favorable IC50value of 143 μM afforded a therapeutic index (IC50/Ki for MMP-9) ratio of 7530, indicating that (R)-ND-336 is not cytotoxic[1].
In Vivo: (R)-ND-336 (50 μg/wound/day for 14 days) accelerates wound healing faster[1].
(R)-ND-336 has an AUC of 1.3 μM?min after topical administration and 35 μM?min following intravenous dosing, for an AUCtop/AUCiv ratio of 3.7%, indicating minimal absorption after topical administration in db/db mice[1].
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