Sotorasib (racemate)
CAS No. : 2252403-56-6
(Synonyms: AMG-510 (racemate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $63 | In-stock |
| 10mg | $99 | In-stock |
| 25mg | $209 | In-stock |
| 50mg | $385 | In-stock |
| 100mg | $605 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-114277A |
| M.Wt: | 560.59 |
| Formula: | C30H30F2N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 3.85 mg/mL (ultrasonic) |
Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib (HY-114277), a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research[1].
In Vivo:Sotorasib racemate (30-100 mg/kg, p.o., QD for 21 d) suppresses NCI-H358 tumor growth in a dose-dependent manner in tumor xenograft mice[1].
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