(+)-(3R,8S)-Falcarindiol

(+)-(3R,8S)-Falcarindiol ((3R,8S)-Falcarindiol; 3 (R),8 (S),9 (Z)-Falcarindiol) is an orally active polyacetylene anti-mycobacterial agent. (+)-(3R,8S)-Falcarindiol exhibits antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and mycobacteria. Co-administration of (+)-(3R,8S)-Falcarindiol with (3R)-falcarinol alters the composition of gut microbiota, reduces colonic tumor lesions and slows down polyp growth. (+)-(3R,8S)-Falcarindiol can be used in research related to tuberculosis and colorectal cancer^[1][2]. IC50 & Target:IC50: 6 μM (Mycobacterium tuberculosis H37Ra)^[1] In Vitro:(+)-(3R,8S)-Falcarindiol (0.20-400 µg/mL; 96 h) potently inhibits the growth of Mycobacterium tuberculosis H37Ra, with an IC₅₀ of 6 μM and a MIC of 24 μM^[1]. In Vivo:Co-administration of (+)-(3R,8S)-Falcarindiol (7 µg/g; oral; continuous administration via diet; for 10 weeks) with (3R)-falcarinol significantly alters the composition of low-abundance members in the intestinal microbiota of rats and reduces colonic tumor lesions^[2].