SGC-AAK1-1
CAS No. : 2247894-32-0
| Size | Price | Stock |
|---|---|---|
| 25mg | $112 | In-stock |
| 100mg | $286 | In-stock |
| 250mg | $485 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-123940 |
| M.Wt: | 427.52 |
| Formula: | C21H25N5O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1].
IC50 & Target: IC50: 270 nM (AAK1)[1].
Ki: 9 nM (AAK1)[1]
In Vitro: SGC-AAK1-1 (1.25 μM) significantly reduces phosphorylation of AP2M1 (T156) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells[1].
SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription[1].
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