Fz7-21
CAS No. : 2247635-23-8
(Synonyms: Ac-LPSDDLEFWCHVMY-NH2)
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $220 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $595 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-P1454 |
| M.Wt: | 1796.05 |
| Formula: | C83H114N18O23S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids[1][2].
IC50 & Target:EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)[1]
In Vitro: Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (0-100μM; 6 h; HEK293-TB cells) impairs Wnt signaling with IC50 value of 100?nM[1].
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (1?μM) blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 value of 50?nM[1].
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (200 μM; 48 h; LGR5-GFP+ stem cells) disrupts LGR5+ stem cell function[1].
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