VUBI1
CAS No. : 2245237-53-8
(Synonyms: SOS1 activator 1)
| Size | Price | Stock |
|---|---|---|
| 1mg | $420 | In-stock |
| 5mg | $1050 | In-stock |
| 10mg | $1700 | In-stock |
| 25mg | $2800 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-111671 |
| M.Wt: | 483.02 |
| Formula: | C26H32ClFN6 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
VUBI1 (SOS1 activator 1) is a benzimidazole derivative and SOS1 activator with a Kd of 44 nM. VUBI1 can significantly activate RAS-GTP and regulate the phosphorylation of ERK. VUBI1 also can serve as a target ligand for synthesizing PROTACs, such as PROTAC SOS1 degrader-1 (HY-145737), to induce SOS1 degradation. VUBI1 can be used in the study of cancer[1][2][3][4]. In Vitro:VUBI1 (Compound 64) (0.3-30 µM; 10 min) increases RAS-GTP levels and biphasically modulates ERK1/2 phosphorylation in HeLa cells (inducing peak levels at low concentrations and suppressing at high concentrations)[1].
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