LIT-001 (free base)
CAS No. : 2245072-20-0
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| Cat. No. : | HY-124733 |
| M.Wt: | 531.67 |
| Formula: | C28H33N7O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 free base improves social interaction in a mouse model of autism[1]. In Vitro: In vitro signaling experiments, LIT-001 free base is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only[1]. In Vivo: LIT-001 free base (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1].
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