BAY-293
CAS No. : 2244904-70-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $432 | In-stock |
| 50mg | $648 | In-stock |
| 100mg | $972 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114398 |
| M.Wt: | 448.58 |
| Formula: | C25H28N4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS[1].
IC50 & Target: IC50: 21 nM (KRAS-SOS1 interaction)[1]
In Vitro: BAY-293 inhibits the activation of RAS in HeLa cells, with IC50 values in the submicromolar range[1].
BAY-293 (595 nM-3580 nM; 72 hours) shows efficient antiproliferative activity against wild-type KRAS cell lines (K-562, MOLM-13) and cell lines with KRASG12C mutation (NCI-H358, Calu-1)[1].
BAY-293 efficiently inhibits pERK levels in K-562 cells after incubation for 60 min without affecting total protein levels of ERK[1].
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