Homo-PROTAC pVHL30 degrader 1
CAS No. : 2244684-49-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $560 | In-stock |
| 100mg | $784 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-111593 |
| M.Wt: | 1179.45 |
| Formula: | C58H82N8O14S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 150 mg/mL;H2O : 25 mg/mL (ultrasonic) |
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.
IC50 & Target:pVHL30[1]
PROTAC[1]
In Vitro: Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].
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